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王華林

抗病毒藥物與基因篩選專家

01

可轉(zhuǎn)化技術(shù)

細(xì)胞與病毒

  • 抗病毒藥物開(kāi)發(fā)
  • 抗病毒基因篩選
  • 病毒與宿主互作

02

個(gè)人簡(jiǎn)介

王華林,1974年生,中國(guó)科學(xué)院武漢病毒研究所研究員、博士生導(dǎo)師,湖北省病毒疾病工程技術(shù)研究中心常務(wù)副主任,分子病毒學(xué)及生物工程技術(shù)學(xué)科組組長(zhǎng),新縱科(湖北)病毒疾病工程技術(shù)有限公司董事長(zhǎng)。

2000至2003年分別在荷蘭和德國(guó)研究所開(kāi)展博士研究工作。重點(diǎn)研究方向包括病毒感染機(jī)理、病毒與宿主相互作用、病毒檢測(cè)診斷新技術(shù)的研發(fā)、抗病毒生物技術(shù)藥物的研發(fā)。承擔(dān)了國(guó)家重點(diǎn)研發(fā)計(jì)劃、計(jì)劃、國(guó)家自然科學(xué)基金、中荷科學(xué)戰(zhàn)略聯(lián)盟項(xiàng)目、手足口病病毒的研究等多項(xiàng)國(guó)家級(jí)科研項(xiàng)目及橫向項(xiàng)目。

在業(yè)內(nèi)完成了多個(gè)第一:首次利用核磁共振技術(shù)發(fā)現(xiàn)F蛋白中的重要功能位點(diǎn);首次揭示桿狀病毒中入侵昆蟲(chóng)和哺乳動(dòng)物細(xì)胞的新途徑。曾榮獲國(guó)家杰出青年基金資助,以及中科院院長(zhǎng)優(yōu)秀獎(jiǎng)學(xué)金、湖北省自然科學(xué)二等獎(jiǎng)、第二屆武漢青年科技獎(jiǎng)等多項(xiàng)獎(jiǎng)勵(lì),并入選第六批“3551光谷人才計(jì)劃”。

在J Virol、Antiviral Res等國(guó)際權(quán)威期刊上發(fā)表SCI研究論文40多篇;申請(qǐng)發(fā)明專利10余項(xiàng),已獲授權(quán)專利5項(xiàng)。

專利:一種乙型肝炎病毒基因分型的方法
公開(kāi)號(hào):CN101402993?申請(qǐng)時(shí)間:2007-11-05

2?專利:中國(guó)棉鈴蟲(chóng)基因工程病毒
公開(kāi)號(hào):CN1291649?申請(qǐng)時(shí)間:2000-11-16

3?專利:用于桿狀病毒滴度測(cè)定的重組細(xì)胞系及其測(cè)定方法
公開(kāi)號(hào):CN103571795A?申請(qǐng)時(shí)間:2013-11-04

4?專利:桿狀病毒的gp64和p35基因的聯(lián)合應(yīng)用
公開(kāi)號(hào):CN1654658?申請(qǐng)時(shí)間:2004-12-27

5?專利:一種基于液相芯片檢測(cè)禽流感病毒H5N1亞型的方法
公開(kāi)號(hào):CN1858249?申請(qǐng)時(shí)間:2006-03-21

6?專利:一種用于檢測(cè)乙型肝炎病毒的生物用品
公開(kāi)號(hào):CN1861807?申請(qǐng)時(shí)間:2006-02-14

7?專利:一種抑制乙型肝炎病毒的天然提取物及其主要活性成份
公開(kāi)號(hào):CN101028382?申請(qǐng)時(shí)間:2007-03-29

8?專利:用于檢測(cè)乙型肝炎病毒耐藥突變位點(diǎn)的引物及方法
公開(kāi)號(hào):CN102181575A?申請(qǐng)時(shí)間:2011-03-18

9?專利:用液相芯片檢測(cè)呼吸道傳染病病原的引物和探針及方法
公開(kāi)號(hào):CN102181576A?申請(qǐng)時(shí)間:2011-03-21

10?專利:用液相芯片檢測(cè)蟲(chóng)媒或接觸傳播病原的引物和探針及方法
公開(kāi)號(hào):CN102181532A?申請(qǐng)時(shí)間:2011-03-21

11?專利:用于提高桿狀病毒對(duì)哺乳動(dòng)物細(xì)胞轉(zhuǎn)導(dǎo)效率的方法
公開(kāi)號(hào):CN102199629A?申請(qǐng)時(shí)間:2011-03-29

12?專利:表達(dá)gp64基因的新型基因工程重組病毒的構(gòu)建方法
公開(kāi)號(hào):CN102382803A?申請(qǐng)時(shí)間:2011-11-08

13?專利:用于檢測(cè)乙型肝炎病毒共價(jià)閉合DNA的生物用品及其應(yīng)用
公開(kāi)號(hào):CN101397592?申請(qǐng)時(shí)間:2008-11-04

14?專利:重組桿狀病毒AcBacΔCC-GP41及其構(gòu)建方法
公開(kāi)號(hào):CN101113460?申請(qǐng)時(shí)間:2007-07-03

15?專利:高效表達(dá)SARS冠狀病毒S蛋白的重組桿狀病毒及構(gòu)建
公開(kāi)號(hào):CN101100680?申請(qǐng)時(shí)間:2007-06-15

1?文章:Molecular identification and phylogenetic analysis of baculoviruses from Lepidoptera.
作者:Johannes A. Jehle,Martin Lange,Hualin Wang,Zhihong Hu,Yongjie Wang,Rüdiger Hauschild,Johannes A Jehle,Martin Lange,R??diger Hauschild引用次數(shù):161?SCI/SSCI?期刊:Virology

2?文章:Proteomics of the Autographa californica nucleopolyhedrovirus budded virions.
作者:RanRan Wang,Fei Deng,Dianhai Hou,Yong Zhao,Lin Guo,Hualin Wang,Zhihong Hu?引用次數(shù):97?SCI/SSCI期刊:Journal of virology

3?文章:An MEC-MR-Coupled System for Biohydrogen Production from Acetate
作者:Sun Min,Sheng GuoPing,Zhang Lei,Xia ChangRong,Mu ZheXuan,Liu XianWei,Wang HuaLin,Yu HanQing,Qi Rong,Yu Tao,Min Sun,Guo-Ping Sheng,Min Yang引用次數(shù):91?SCI/SSCI?期刊:Environmental Science and Technology

4?文章:Biological activity and field efficacy of a genetically modified Helicoverpa armigera SNPV expressing an insect-selective toxin from a chimeric promoter. Biol Control
作者:Xiulian Sun,Xinwen Chen,Johannes A Jehle,Wopke van der Werf,Just M Vlak,Zhihong Hu,Hualin Wang,Xincheng Sun,Chaomei Peng,Dengming Pan引用次數(shù):86?SCI/SSCI?期刊:Biological Control

5?文章:Characterization and phylogenetic analysis of the chitinase gene from the Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus
作者:Hualin Wang,Dong Wu,Fei Deng,Huiyin Peng,Xinwen Chen,Hilary Lauzon,Basil M. Arif,Johannes A. Jehle,Zhihong Hu,Hualin Wang,Dong Wu,Zhihong Hu引用次數(shù):76?SCI/SSCI?期刊:Virus Research

6?文章:Reassortment and migration analysis of Crimean-Congo hemorrhagic fever virus.
作者:Zhaorui Zhou,Fei Deng,Na Han,Hualin Wang,Surong Sun,Yujiang Zhang,Zhihong Hu,Simon Rayner引用次數(shù):65?SCI/SSCI?期刊:Journal of General Virology

7?文章:Bollworm responses to release of genetically modified Helicoverpa armigera nucleopolyhedroviruses in cotton.
作者:Xiulian Sun,Xinwen Chen,Zhongxin Zhang,Hualin Wang,Felix J J A Bianchi,Huiyin Peng,Just M Vlak,Zhihong Hu,Xiulian Sun,Xinwen Chen,Zhihong Hu引用次數(shù):63?SCI/SSCI?期刊:Journal of invertebrate pathology

8?文章:Open reading frame 94 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus encodes a novel conserved occlusion-derived virion protein, ODV-EC43
作者:MINGGANG FANG,HANZHONG WANG,HUALIN WANG,LI YUAN,XINWEN CHEN,VLAK02Just M.,ZHIHONG HU,Minggang Fang,Hanzhong Wang,Zhihong Hu引用次數(shù):58?SCI/SSCI?期刊:Journal of General Virology

9?文章:Identification of functional domains required for HearNPV P10 filament formation
作者:Chunsheng Dong,Dan Li,Gang Long,Fei Deng,Hualin Wang,Zhihong Hu,Chunsheng Dong,Dan Li,Zhihong Hu引用次數(shù):47?SCI/SSCI?期刊:Virology

10?文章:Microbe-assisted sulfide oxidation in the anode of a microbial fuel cell.
作者:Sun Min,Mu ZheXuan,Chen YouPeng,Sheng GuoPing,Liu XianWei,Chen YongZhen,Zhao Yue,Wang HuaLin,Yu HanQing,Wei Li,Min Sun,Zhe-Xuan Mu,Fang Ma引用次數(shù):46?SCI/SSCI?期刊:Environmental science & technology

11?文章:Photosynthetic physiology and growth as a function of colony size in the cyanobacterium Nostoc sphaeroides
作者:Basil M. Arif,Zhihong Hu,Johannes A. Jehle,Hilary Lauzon,Hualin Wang,Dong Wu,Fei Deng,Huiyin Peng,Xinwen Chen引用次數(shù):42?SCI/SSCI?期刊:European Journal of Phycology

12?文章:Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus
作者:Dianhai Hou,Leike Zhang,Zhihong Hu?引用次數(shù):38?SCI/SSCI?期刊:Journal of Virology

13?文章:Functional studies of per os infectivity factors of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus
作者:Jingjiao Song,Ranran Wang,Fei Deng,Hualin Wang,Zhihong Hu?引用次數(shù):38?SCI/SSCI期刊:Journal of General Virology

14?文章:Autographa californica multicapsid nucleopolyhedrovirus efficiently infects Sf9 cells and transduces mammalian cells via direct fusion with the plasma membrane at low pH.
作者:Sicong Dong,Manli Wang,Zhijuan Qiu,Fei Deng,Just M. Vlak,Zhihong Hu,Hualin Wang?引用次數(shù):31SCI/SSCI?期刊:Journal of Virology

15?文章:Nucleotide Sequence and Transcriptional Analysis of a Putative Basic DNA-Binding Protein of Helicoverpa armigera Nucleopolyhedrovirus
作者:Hualin Wang,Xinwen Chen,Hanzhong Wang,Basil M. Arif,Just M. Vlak,Zhihong Hu,Hualin Wang,Xinwen Chen,Zhihong Hu引用次數(shù):30?SCI/SSCI?期刊:Virus Genes

16?文章:Open reading frame 132 of Helicoverpa armigera nucleopolyhedrovirus encodes a functional per os infectivity factor (PIF-2).
作者:Minggang Fang,Yingchao Nie,Qian Wang,Fei Deng,Ranran Wang,Hanzhong Wang,Hualin Wang,Just M Vlak,Xinwen Chen,Zhihong Hu,Minggang Fang,Yingchao Nie,Zhihong Hu,Minggang Fang,Yingchao Nie,Zhihong Hu引用次數(shù):29?SCI/SSCI?期刊:The Journal of general virology

17?文章:The heptad repeats region is essential for AcMNPV P10 filament formation and not the proline-rich or the C-terminus basic regions.
作者:Chunsheng Dong,Fei Deng,Dan Li,Hualin Wang,Zhihong Hu?引用次數(shù):26?SCI/SSCI?期刊:Virology

18?文章:Open reading frame Bm21 of Bombyx mori nucleopolyhedrovirus is not essential for virus replication in vitro, but its deletion extends the median survival time of infected larvae.
作者:Jinshan Huang,Bifang Hao,Fei Deng,Xiulian Sun,Hualin Wang,Zhihong Hu?引用次數(shù):22?SCI/SSCI期刊:The Journal of general virology

19?文章:Deletion of a Helicoverpa armigera nucleopolyhedrovirus gene encoding a virion structural protein (ORF107) increases the budded virion titre and reduces in vivo infectivity
作者:Xiaoyu Pan,Gang Long,RanRan Wang,Songwang Hou,Huiyuan Wang,Yueting Zheng,Xiulian Sun,Marcel Westenberg,Fei Deng,Hualin Wang,Xiaoyu Pan,Gang Long,Zhihong Hu引用次數(shù):19?SCI/SSCI?期刊:Journal of General Virology

20?文章:棉鈴蟲(chóng)核多角體病毒p10基因的序列及轉(zhuǎn)錄分析
作者:王華林,陳新文,Vlak.J.M,胡志紅?引用次數(shù):18??期刊:《病毒學(xué)報(bào)》

21?文章:A functional F analogue of AcMNPV GP64 from the Agrotis segetum granulovirus
作者:Feifei Yin,Manli Wang,Ying Tan,Fei Deng,Just M Vlak,Zhihong Hu,Hualin Wang?引用次數(shù):16?SCI/SSCI期刊:Journal of Virology

22?文章:液相芯片MASA技術(shù)用于兒童呼吸道感染病原學(xué)研究
作者:夏駿,鄧菲,金潤(rùn)銘,王琳,王麗娜,胡志紅,劉芳?引用次數(shù):14??期刊:《中國(guó)病毒學(xué)》

23?文章:Angiotensin-converting enzyme 2 (ACE2) fromraccoon dog can serve as an efficient receptor forthe spike protein of severe acute respiratorysyndrome coronavirus
作者:Xu Lili,Zhang YanFang,Liu Yun,Chen ZhiWei,Deng HongKui,Ma ZhongBin,Wang HuaLin,Hu ZhiHong,Deng Fei引用次數(shù):14?SCI/SSCI?期刊:The Journal of general virology

24?文章:液相芯片MASA技術(shù)用于兒童呼吸道感染病原學(xué)研究
作者:無(wú)?引用次數(shù):13??期刊:

25?文章:Development and Evaluation of a Multitarget Real-Time Taqman Reverse Transcription-PCR Assay for Detection of the Severe Acute Respiratory Syndrome-Associated Coronavirus and Surveillance for an Ap…
作者:Wenqian Hu,Zhihong Hu,Ze Chen,Hanzhong Wang,Bingke Bai,Xuefang An,Lijun Tang,Jihong Yang,Hualin Wang引用次數(shù):12?SCI/SSCI?期刊:Journal of clinical microbiology

26?文章:用液相芯片方法檢測(cè)禽流感病毒H5N1亞型的研究
作者:夏駿,鄧菲,胡志紅,劉芳,王華林?引用次數(shù):12??期刊:檢驗(yàn)醫(yī)學(xué)

27?文章:用液相芯片方法檢測(cè)禽流感病毒H5N1 亞型的研究
作者:夏駿,鄧菲,胡志紅,劉芳,王華林?引用次數(shù):12??期刊:浙江省醫(yī)學(xué)檢驗(yàn)學(xué)學(xué)術(shù)年會(huì)

28?文章:Variants of open reading frame Bm126 in wild-type Bombyx mori nucleopolyhedrovirus isolates exhibit functional differences
作者:Bifang Hao,Jinshan Huang,Xiulian Sun,Fei Deng,Yanfang Zhang,Hualin Wang,Hong Chen,Zhihong Hu引用次數(shù):10?SCI/SSCI?期刊:The Journal of general virology

29?文章:油桐尺蠖單粒包埋核型多角體病毒(BusuNPV)BamHI—H片段的序列分析
作者:羅保君,Arif.?引用次數(shù):9??期刊:《中國(guó)病毒學(xué)》

30?文章:ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex
作者:Huachao Huang,Manli Wang,Fei Deng,Hualin Wang,Zhihong Hu?引用次數(shù):9?SCI/SSCI?期刊:Virology

31?文章:Construction of the Bac-to-Bac System of Bombyx mori Nucleopolyhedroviru
作者:Huang Jin-shan,Hao Bi-fang,Sun Xiu-lian,Deng Fei,Wang Hua-lin,Hu Zhi-hong?引用次數(shù):9?期刊:《中國(guó)病毒學(xué)》

32?文章:棉鈴蟲(chóng)單核衣殼核多角體病毒幾丁質(zhì)酶基因的克隆與表達(dá)
作者:吳東,王華林?引用次數(shù):7??期刊:《中國(guó)病毒學(xué)》

33?文章:棉鈴蟲(chóng)單核衣殼核多角體病毒幾丁質(zhì)酶基因的克隆與表達(dá)
作者:吳 東,王華林,鄧 菲,陳新文,彭輝銀,胡志紅?引用次數(shù):7??期刊:《中國(guó)病毒學(xué)》

34?文章:棉鈴蟲(chóng)核多角體病毒細(xì)胞凋亡抑制基因iap~3的序列分析
作者:王華林,胡志紅,孫修煉,Just M.Vlak,陳新文?引用次數(shù):7??期刊:《中國(guó)病毒學(xué)》

35?文章:The ha72 core gene of baculovirus is essential for budded virus production and occlusion-derived virus embedding, and amino acid K22 plays an important role in its function.
作者:Huachao Huang,Manli Wang,Fei Deng,Dianhai Hou,Basil M. Arif,Hualin Wang,Zhihong Hu?引用次數(shù):7SCI/SSCI?期刊:Journal of virology

36?文章:Helicoverpa armigera nucleopolyhedrovirus occlusion-derived virus-associated protein, HA100, affects oral infectivity in vivo but not virus replication in vitro.
作者:Sijiani Luo,Yanfang Zhang,Xushi Xu,Marcel Westenberg,Just M Vlak,Hualin Wang,Zhihong Hu,Fei Deng引用次數(shù):7?SCI/SSCI?期刊:The Journal of general virology

37?文章:Identification and functional analysis of inter-subunit disulfide bonds of the F protein of Helicoverpa armigera nucleopolyhedrovirus
作者:Feifei Yin,Manli Wang,Ying Tan,Fei Deng,Just M. Vlak,Zhihong Hu,Hualin Wang?引用次數(shù):6?SCI/SSCI期刊:The Journal of general virology

38?文章:Helicoverpa armigera nucleopolyhedrovirus ODV associated protein, HA100, affects oral infectivity in vivo but not virus replication in vitro
作者:Sijiani Luo,Yanfang Zhang,Xushi Xu,Marcel Westenberg,Just M. Vlak,Hualin Wang,Zhihong Hu,Fei Deng引用次數(shù):6?SCI/SSCI?期刊:Journal of General Virology

39?文章:適合棉鈴蟲(chóng)細(xì)胞HzAm1生長(zhǎng)的培養(yǎng)基篩選及低血清馴化
作者:張佑紅,王華林,朱雄偉,秦琴,陳燕,呂中,馬潔,張菁?引用次數(shù):5??期刊:生物工程學(xué)報(bào)

40?文章:SARS病毒N蛋白、E蛋白在大腸桿菌中的表達(dá)與鑒定
作者:何濤,胡志紅,方明剛,王華林,楊繼紅,王漢中?引用次數(shù):4??期刊:《中國(guó)病毒學(xué)》

41?文章:缺失p10基因的重組棉鈴蟲(chóng)病毒導(dǎo)致多角體囊膜包裝不完整
作者:董春升,鄧菲,袁麗,潘小玉,王華林,胡志紅?引用次數(shù):4??期刊:《Virologica Sinica》

42?文章:人巨細(xì)胞病毒 pp65基因重組蛋白在昆蟲(chóng)細(xì)胞中的表達(dá)與分析
作者:邱紅玉,胡志紅,劉嵐,吳東,王華林,鄧菲,孫永玉?引用次數(shù):4??期刊:《中華傳染病雜志》

43?文章:Betabaculovirus F proteins showed different efficiencies when rescuing the infectivity of gp64-null Autographa californica nucleopolyhedrovirus.
作者:Feifei Yin,Manli Wang,Ying Tan,Fei Deng,Just M. Vlak,Zhihong Hu,Hualin Wang?引用次數(shù):4?SCI/SSCI期刊:Virology

44?文章:HearNPV在生長(zhǎng)對(duì)數(shù)期與平臺(tái)期宿主細(xì)胞中的復(fù)制差異分析
作者:代文濤,韓霄,王華林,胡志紅,鄧菲?引用次數(shù):4??期刊:《病毒學(xué)報(bào)》

45?文章:Genome Sequence and Analysis of Buzura suppressaria Nucleopolyhedrovirus: A Group II Alphabaculovirus
作者:Zheng Zhu,Feifei Yin,Xiaoping Liu,Dianhai Hou,Jun Wang,Lei Zhang,Basil Arif,Hualin Wang,Fei Deng,Zhihong Hu,Zheng Zhu,Feifei Yin,Zhihong Hu引用次數(shù):3?SCI/SSCI?期刊:PLOS ONE

46?文章:Complete Genome Sequences of Two Crimean-Congo Hemorrhagic Fever Viruses Isolated in China
作者:Zhaorui Zhou,Tianxian Li,Zhihong Hu,Weiwei Meng,Fei Deng,Han Xia,Surong Sun,Manli Wang,Hualin Wang,Yujiang Zhang引用次數(shù):3??期刊:Genome Announcements

47?文章:An improved culture system for virus isolation and detection
作者:Yu-chen XIA,Zhi-hong HU,Zhi-juan QIU,Zhong-bin MA,Hua-lin WANG,Fei DENG?引用次數(shù):3?期刊:中國(guó)病毒學(xué)

48?文章:Proteomics Analysis of HearNPV Identified Two New ODV associated Proteins, HA44 and HA100
作者:Fei Deng,Ranran Wang,Minggang Fang,Yue Jiang,Xushi Xu,Hanzhong Wang,Xinwen Chen,Basil M. Arif,Lin Guo,Hualin Wang,Zhihong Hu,Fei Deng??Ranran Wang,Minggang Fang,Zhihong Hu引用次數(shù):3?SCI/SSCI?期刊:Journal of Virology

49?文章:免疫熒光及雙抗體夾心ELISA在人狂犬病檢測(cè)中的應(yīng)用
作者:孫來(lái)晶,徐葛林,王華林,吳杰,胡志紅,周亦武?引用次數(shù):3??期刊:法醫(yī)學(xué)雜志

50?文章:表達(dá)GP64的重組HaSNPV的構(gòu)建研究
作者:王舒,王華林,鄧菲,吳東,龍鋼,袁麗,胡志紅?引用次數(shù):2??期刊:中國(guó)病毒學(xué)

51?文章:Genomic sequencing and analysis of Sucra jujuba nucleopolyhedrovirus.
作者:Xiaoping Liu,Feifei Yin,Zheng Zhu,Dianhai Hou,Jun Wang,Lei Zhang,Manli Wang,Hualin Wang,Zhihong Hu,Fei Deng,Xiaoping Liu,Feifei Yin,Fei Deng引用次數(shù):2?SCI/SSCI?期刊:PLoS ONE

52?文章:Substrate Effect on the Phase Behavior of Polymer Brushes with Lattice Density Functional Theory
作者:Cheng Lian,Shuangliang Zhao,Xueqian Chen,Wenjie Lv,Xia Han,Hualin Wang,Honglai Liu?引用次數(shù):2?期刊:Macromolecular Theory and Simulations

53?文章:Incorporation of GP64 into Helicoverpa armigera NPV enhances virus infectivity in vivo and in vitro.
作者:Shu Shen,Yinyin Gan,Manli Wang,Zhihong Hu,Hualin Wang,Fei Deng?引用次數(shù):2?SCI/SSCI期刊:The Journal of general virology

54?文章:HaSNPV的9個(gè)基因的轉(zhuǎn)錄譜分析
作者:代文濤,鄧菲,王華林,袁麗,胡志紅?引用次數(shù):2??期刊:《中國(guó)病毒學(xué)》

55?文章:狂犬病死亡的法醫(yī)學(xué)鑒定3例
作者:孫來(lái)晶,周亦武,肖愛(ài)武,劉良,王華林?引用次數(shù):1??期刊:法醫(yī)學(xué)雜志

56?文章:幾丁質(zhì)酶在農(nóng)林病蟲(chóng)害生物防治的應(yīng)用及研究進(jìn)展
作者:彭輝銀,張雙民,吳東,王華林?引用次數(shù):1??期刊:中國(guó)昆蟲(chóng)學(xué)會(huì)2000年學(xué)術(shù)年會(huì)

57?文章:Functional studies of per os infectivity factor 3 of Helicoverpa armigera nucleopolyhedrovirus.
作者:Jingjiao Song,Manli Wang,Huachao Huang,Xin Luo,Fei Deng,Hualin Wang,Zhihong Hu,Jingjiao Song,Manli Wang,Zhihong Hu引用次數(shù):1?SCI/SSCI?期刊:Journal of General Virology

58?文章:Production and characterization of monoclonal antibodies against the hemagglutinin of H5N1 and antigenic investigation of avian influenza H5N1 viruses isolated from China.
作者:Jie Wei,Bing Yan,Ze Chen,Tianxian Li,Fei Deng,Hualin Wang,Zhihong Hu?引用次數(shù):1?SCI/SSCI期刊:Canadian Journal of Microbiology

59?文章:一步法RT-PCR檢測(cè)人狂犬病毒初探
作者:孫來(lái)晶,王華林,徐葛林,吳杰,胡志紅,周亦武?引用次數(shù):1??期刊:中國(guó)法醫(yī)學(xué)雜志

60?文章:一株基因組缺失24kb的棉鈴蟲(chóng)單粒包埋核多角體病毒細(xì)菌人工染色體仍具有感染性
作者:黃弋,胡志紅,王華林,陳新文,Valk Just M,王漢中?引用次數(shù):0?期刊:《廿一世紀(jì)微生物學(xué)發(fā)展前沿與應(yīng)用新技術(shù)研討會(huì)論文摘要集》

61?文章:國(guó)內(nèi)外生物醫(yī)藥產(chǎn)品的現(xiàn)狀及發(fā)展趨勢(shì)
作者:王華林,王漢中?引用次數(shù):0??期刊:湖北科技論壇

62?文章:Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish
作者:Ziru Dai,Hualin Wang,Xia Jin,Houpeng Wang,Jiangyan He,Mugen Liu,Zhan Yin,Yonghua Sun,Qiyong Lou,Ziru Dai,Hualin Wang,Qiyong Lou引用次數(shù):0??期刊:American journal of physiology. Endocrinology and metabolism

63?文章:桿狀病毒病毒粒子結(jié)構(gòu)與口服感染和系統(tǒng)感染的關(guān)系
作者:侯典海,王曼麗,鄧菲,王華林,胡志紅?引用次數(shù):0??期刊:《生命科學(xué)》

64?文章:Identification and functional analysis of inter-subunit disulfide bonds of F protein of HearNPV.
作者:Feifei Yin,Manli Wang,Ying Tan,Fei Deng,Just M Vlak,Zhihong Hu,Hualin Wang,Feifei Yin,Manli Wang,Ying Tan引用次數(shù):0?SCI/SSCI?期刊:Journal of General Virology

65?文章:棉鈴蟲(chóng)核多角體病毒口服感染相關(guān)基因的功能研究
作者:宋景嬌,鄧菲,王華林,胡志紅?引用次數(shù):0??期刊:中國(guó)科學(xué)院大學(xué)

66?文章:基于液相芯片技術(shù)的呼吸道病原體多重檢測(cè)技術(shù)的建立
作者:袁勤芬,尹飛飛,王華林,劉萬(wàn)紅?引用次數(shù):0??期刊:醫(yī)學(xué)檢驗(yàn)與臨床

67?文章:Free thiols in Japanese Encephalitis Virus Glycoprotein E are Essential for Virus Entry
作者:Du Ruikun,Feifei Yin,Manli Wang,Fei Deng,Zhihong Hu,Hualin Wang?引用次數(shù):0?期刊:湖北省暨武漢微生物學(xué)會(huì)會(huì)員代表大會(huì)暨學(xué)術(shù)年會(huì)

68?文章:棉鈴蟲(chóng)核多角體病毒膜融合蛋白N-糖基化修飾的突變和功能研究
作者:沈姝,王曼麗,李鑫,李淑芬,鄧菲,Just M.Valk,Ineke Braakman,胡志紅,王華林?引用次數(shù):0?期刊:湖北省暨武漢微生物學(xué)會(huì)會(huì)員代表大會(huì)暨學(xué)術(shù)年會(huì)

69?文章:Helicoverpa armigera nucleopolyhedrovirus ODV-E66 is involved in the incorporation of occlusion-derived virus into polyhedra but not important for oral infectivity and BV replication
作者:Dianhai Hou,Sijiani Luo,Ranran Wang,Manli Wang,Hualin Wang,Zhihong Hu,Fei Deng?引用次數(shù):0?期刊:湖北省暨武漢微生物學(xué)會(huì)會(huì)員代表大會(huì)暨學(xué)術(shù)年會(huì)

70?文章:Identification of the Epitopes of Monoclonal Antibodies against P74 of Helicoverpa armigera Nucleopolyhedrovirus
作者:Limin,Liao,Dianhai,Huachao,Huang,Manli,Wang,Deng,Hualin,Wang?引用次數(shù):0??期刊:中國(guó)病毒學(xué)

71?文章:AcMNPV FP25K蛋白調(diào)控BV/ODV形成的分子機(jī)制
作者:李淑芬,王曼麗,沈姝,鄧菲,胡志紅,王華林?引用次數(shù):0?期刊:鄂粵微生物學(xué)學(xué)術(shù)年會(huì)-湖北省暨武漢微生物學(xué)會(huì)成立六十年慶祝大會(huì)

72?文章:Functional studies on the per os infectivity factor 3 (PIF3) of HearNPV.
作者:Jingjiao Song,Manli Wang,Huachao Huang,Xin Luo,Fei Deng,Hualin Wang,Zhihong Hu?引用次數(shù):0SCI/SSCI?期刊:Journal of General Virology

73?文章:比較蛋白質(zhì)組研究顯示桿狀病毒兩種子代病毒粒子之間結(jié)構(gòu)與功能存在重要差別
作者:侯典海,張磊砢,鄧菲,方偉,王冉冉,劉希佳,郭林,Simon Raynera,陳新文,王華林?引用次數(shù):0?期刊:鄂粵微生物學(xué)學(xué)術(shù)年會(huì)——湖北省暨武漢微生物學(xué)會(huì)成立六十年慶祝大會(huì)

74?文章:桿狀病毒囊膜蛋白融合肽的NMR結(jié)構(gòu)和功能研究
作者:談瑩,姜凌,王曼麗,尹飛飛,鄧菲,劉買利,胡志紅,王華林?引用次數(shù):0??期刊:全國(guó)波譜學(xué)學(xué)術(shù)會(huì)議

75?文章:AgseGV的膜融合蛋白是AcMNPV GP64的功能類似物
作者:尹飛飛,王曼麗,談瑩,鄧菲,胡志紅,王華林?引用次數(shù):0?期刊:《第七屆全國(guó)病毒學(xué)學(xué)術(shù)研討會(huì)暨第二屆武漢現(xiàn)代病毒學(xué)國(guó)際研討會(huì)論文集》

76?文章:熒光定量PCR檢測(cè)穩(wěn)定表達(dá)乙型肝炎病毒的細(xì)胞系中和病人血清中的共價(jià)閉合環(huán)狀DNA
作者:許君,丘志娟,鄧菲,胡志紅,王華林?引用次數(shù):0??期刊:《“環(huán)境與健康”學(xué)術(shù)研討會(huì)論文摘要集》

77?文章:中國(guó)棉鈴蟲(chóng)核多角體病毒HearNPV G4株ODV結(jié)構(gòu)蛋白的定位研究
作者:王冉冉,鄧菲,王華林,胡志紅?引用次數(shù):0??期刊:《“環(huán)境與健康”學(xué)術(shù)研討會(huì)論文摘要集》

78?文章:棉鈴蟲(chóng)核多角體病毒ODV結(jié)構(gòu)蛋白組分間相互作用的研究
作者:彭珂,吳明枝,董春升,鄧菲,王華林,胡志紅?引用次數(shù):0??期刊:全國(guó)病毒學(xué)學(xué)術(shù)研討會(huì)暨武漢現(xiàn)代病毒學(xué)國(guó)際研討會(huì)

79?文章:Deletion of p10 from the genome of HaSNPV results in a faulty polyhedral envelope
作者:Dong Chunsheng,Deng Fei,Yuan Li,Pan Xiaoyu,Wang Hualin,Hu Zhihong?引用次數(shù):0?期刊:《中國(guó)病毒學(xué)(英文版)》

03

工作學(xué)習(xí)經(jīng)歷

工作經(jīng)歷

- Present

中國(guó)科學(xué)院武漢病毒研究所

研究員、博士生導(dǎo)師

-Present

湖北省病毒疾病工程技術(shù)研究中心

常務(wù)副主任,分子病毒學(xué)及生物工程技術(shù)學(xué)科組組長(zhǎng)

-Present

新縱科(湖北)病毒疾病工程技術(shù)有限公司

董事長(zhǎng)

學(xué)習(xí)經(jīng)歷

1997

復(fù)旦大學(xué)

微生物專業(yè)? 理學(xué)學(xué)士

2000

中科院武漢病毒研究所

碩士

2000-2003

中科院水生生物研究所

博士

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