本科及碩士畢業(yè)于南開大學,2009年于弗羅里達大學取得博士學位,先后在特拉華大學和勞倫斯伯克利國家實驗室工作,2014年開始在中科院天津工生所工作。主要研究方向為微生物合成生物學與代謝工程?,F(xiàn)從事合成生物學技術(shù)方法的創(chuàng)建與運用,CO2固定,合成氣生物轉(zhuǎn)化等方面的研究。在主流學術(shù)期刊Metab Eng, ACS Synth., Bio.l, Microb. Cell Fact., ChemComm., J. Bacteriol., AEM發(fā)表SCI論文20篇以上,申請國際專利一項。
研究成果
構(gòu)建一個合成生物學工具用于在非模型細菌,野生細菌中建立復雜代謝途徑;并成功基因改造R.eutropha,Klebsiella等非模式菌,獲得開創(chuàng)性應用;?
發(fā)明一種新的基因操作方法用于連續(xù)向細菌染色體加入DNA片段,獲得專利,基因改造Clostridium菌株增加丁醇產(chǎn)量;?
成功從環(huán)境樣品中分離并改造細菌E. asburia JDR1,通過代謝工程改造E. asburiae JDR-1從半纖維素水解產(chǎn)物中生產(chǎn)乙醇或者乳酸。
發(fā)表論文
(1) Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli, Metab Eng., 2017, 通訊作者
(2) The CRISPR/Cas9-facilitated multiplex pathway optimization (CFPO) technique and its application to improve the Escherichia coli xylose utilization pathway., Metab Eng., 2017, 通訊作者
(3) Improving Succinate Productivity by Engineering a Cyanobacterial CO2 Concentrating System (CCM) in Escherichia coli., Biotechnol J., 2017, 通訊作者
(4) Membrane engineering – A novel strategy to enhance the production and accumulation of β-carotene in Escherichia coli., Metab Eng., 2017, 通訊作者
(5) A novel point mutation in RpoB improves osmotolerance and succinic acid production in Escherichia coli., BMC biotechnology, 2017, 第 4 作者
(6) Construction of a novel anaerobic pathway in Escherichia coli for propionate production, BMC biotechnology, 2017, 通訊作者
(7) Type IIs restriction based combinatory modulation technique for metabolic pathway optimization, Microbial Cell Factories, 2017, 通訊作者
(8) Development of a modularized two-step (M2S) chromosome integration technique for integration of multiple transcription units in Saccharomyces cerevisiae, Biotechnology for Biofuels, 2016, 通訊作者
(9) Development of a fast and easy method for Escherichia coli genome editing with CRISPR/Cas9, Microbial Cell Factories, 2016, 通訊作者
(10) Engineering Corynebacterium glutamicum for violacein hyper production, Microbial Cell Factories, 2016, 通訊作者
(11) Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli, Microbial Cell Factories, 2016, 第 3 作者
(12) End-to-end automated microfluidic platform for synthetic biology: from design to functional analysis, Journal of Biological Engineering, 2016, 第 4 作者
(13) Cross-Platform Laboratory Automation system, ACS Synth. Biol, 2014, 第 4 作者
(14) Overexpression of the Lactobacillus plantarum peptidoglycan biosynthesis murA2 gene increases the tolerance of Escherichia coli to alcohols and enhances ethanol production, BIOENERGY AND BIOFUELS, 2014, 第 2 作者
(15) Developing and Applying a Broad-Host Synthetic Biology Tool Box for Metabolic Engineering of Ralstonia eutropha for Hydrocarbon Production., Microb Cell Fact, 2013, 第 1 作者
(16) Functionalizing Bacterial Cell Surfaces with a Phage Protein, Chem Comm, 2013, 第 3 作者
(17) PaR-PaR Laboratory Automation platform, ACS Synth. Biol, 2012, 第 4 作者
(18) SpoIIE is necessary for asymmetric division, sporulation, and the expression of σF, σE, and σG but does not control solvent production in Clostridium acetobutylicum., J. Bacteriol., 2011, 第 1 作者
(19)? Complete fermentation of xylose and methylglucuronoxylose derived from methylglucuronoxylan by Enterobacter asburiae strain JDR-1, Applied and Environmental Microbilogy, 2009, 第 1 作者
(20) Genetic engineering Enterobacter asburiae strain JDR-1 for efficient ethanol production from hemicellulose hydrolysate, Applied and Environmental Microbilogy, 2009, 第 1 作者
(21) Genetic engineering of Enterobacter asburiae strain JDR-1 for efficient latic acid production from hemicellulose hydrolysate, Biotechnology Letters, 2009, 第 1 作者